Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606
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چکیده
منابع مشابه
Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606
Alzheimer's disease (AD) is characterized neuropathologically by an abundance of 1) neuritic plaques, which are primarily composed of a fibrillar 42-amino-acid amyloid-β peptide (Aβ), as well as 2) neurofibrillary tangles composed of aggregates of hyperphosporylated tau. Elevations in the concentrations of the Aβ42 peptide in the brain, as a result of either increased production or decreased cl...
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ژورنال
عنوان ژورنال: Journal of Pharmacology and Experimental Therapeutics
سال: 2017
ISSN: 0022-3565,1521-0103
DOI: 10.1124/jpet.117.240861